Nurse Jackie S1 - "Nurse Jackie" is a half-hour comedy that is at turns wicked, heartbreaking and funny. Edie Falco stars as the title character Jackie O'Hurley, a strong-willed and brilliant -- but very flawed -- emergency room nurse in a complicated New York City hospital. A lapsed Catholic with an occasional weakness for Vicodin and Adderall to get her through the days, Jackie keeps the hospital balanced with her own kind of justice. Every day is a high wire act of juggling patients, doctors, fellow nurses and her own indiscretions.